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Hum. Reprod. Advance Access published online on April 4, 2006
Human Reproduction, doi:10.1093/humrep/del008
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received October 13, 2005
Revised December 19, 2005
Accepted January 5, 2006

Article

Relationship between human sperm-hyaluronan binding assay and fertilization rate in conventional in vitro fertilization

Hong Ye 1, Guo-ning Huang 1, Yang Gao 1, and De Yi Liu 2 *

1 Reproductive and Genetics Institute, Chongqing Obstetrics and Gynecology Hospital, Chongqing, China
2 Department of Obstetrics and Gynecology, University of Melbourne, Royal Women’s Hospital, Carlton, Victoria, Australia

* To whom correspondence should be addressed.
De Yi Liu, E-mail: dyl{at}unimelb.edu.au


  Abstract

BACKGROUND: Sperm-hyaluronan-binding assay (HBA) is one of the commercial kits being marketed for routine testing of sperm maturity and fertility. However, there is no report of whether the HBA can provide additional information over standard semen analysis for sperm-fertilizing ability. The objective of this study was to investigate the relationship between HBA and fertilization rate in conventional IVF. METHODS: A total of 175 IVF patients with ≥3 mature oocytes inseminated were included in the study. Both the standard semen analysis and the HBA were performed on the same ejaculated sperm samples used for IVF treatments. Relationships between the semen analysis and the HBA results and fertilization rate were analysed by both the Spearman test and the multivariate logistic regression analysis. RESULTS: Both total and progressive sperm motility and normal morphology were highly correlated with HBA scores. While both normal sperm morphology and HBA scores were statistically significantly related to fertilization rates, the HBA was less significant than normal sperm morphology. The HBA does not provide additional information for identifying patients with a poor fertilization rate. CONCLUSION: HBA is highly significantly correlated with sperm motility and morphology but is less significant than sperm morphology in relation to the fertilization rate in IVF. Thus, the clinical predictive value of HBA for sperm-fertilizing ability in vitro is limited.

Keywords: clinical IVF/semen analysis/sperm-hyaluronan-binding assay.
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