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Hum. Reprod. Advance Access published online on February 17, 2006

Human Reproduction, doi:10.1093/humrep/del021
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received August 29, 2005
Revised December 10, 2005
Accepted January 11, 2006

Article

Perifollicular vascularity in poor ovarian responders during IVF

Anita Kan 1, Ernest Hung Yu Ng 1 *, William Shu Biu Yeung 1, and Pak Chung Ho 1

1 Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, People’s Republic of China

* To whom correspondence should be addressed.
Ernest Hung Yu Ng, E-mail: nghye{at}hkucc.hku.hk


   Abstract

BACKGROUND: Normal ovarian responders who have follicles with good vascularity shown by power Doppler scanning are associated with a better pregnancy rate following IVF treatment. This study evaluated the significance of perifollicular vascularity and follicular fluid hormonal profile in poor responders who developed ≤3 dominant follicles. METHODS: Before oocyte retrieval, they underwent power Doppler examination for perifollicular vascularity. Patients who had all follicles with low-grade vascularity were classified as Group A, whereas those with at least one follicle with high-grade vascularity were Group B. Their follicular fluid concentrations of estradiol (E2), progesterone, HCG, vascular endothelial growth factor (VEGF) and inhibin B were measured. RESULTS: A total of 58 consecutive patients were recruited: 38 in Group A and 20 in Group B. Implantation rate, clinical pregnancy rate and follicular fluid hormonal concentrations were comparable for Groups A and B. Multiple pregnancy and live birth rates appeared higher, whereas miscarriage rate were lower in Group B than Group A, but these differences did not reach statistical significance. CONCLUSION: There were no significant differences in the implantation, clinical pregnancy and live birth rates among poor responders with and without high-grade perifollicular vascularity.

Keywords: follicular fluid/perifollicular vascularity/poor ovarian response.
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