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Hum. Reprod. Advance Access published online on March 3, 2006
Human Reproduction, doi:10.1093/humrep/del052
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received December 21, 2005
Revised January 25, 2006
Accepted January 27, 2006

Article

Pretreatment with transdermal testosterone may improve ovarian response to gonadotrophins in poor-responder IVF patients with normal basal concentrations of FSH

Juan Balasch 1 *, Francisco Fábregues 1, Joana Peñarrubia 1, Francisco Carmona 1, Roser Casamitjana 2, Montserrat Creus 1, Dolors Manau 1, Gemma Casals 1, and Juan A. Vanrell 1

1 Institut Clínic of Gynecology, Obstetrics and Neonatology, University of Barcelona, Barcelona, Spain
2 Hormonal Laboratory, Hospital Clínic-Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

* To whom correspondence should be addressed.
Juan Balasch, E-mail: jbalasch{at}ub.edu


  Abstract

BACKGROUND: Treatment of poor-responder patients to controlled ovarian stimulation for assisted reproduction, who have normal basal FSH concentrations, is one of the most difficult challenges in reproductive medicine. This study investigated the usefulness of testosterone pretreatment in such patients. METHODS: Prospective, therapeutic, self-controlled clinical trial including 25 consecutive infertile patients who had a background of the first and second IVF treatment cycle cancellations due to poor follicular response, in spite of vigorous gonadotrophin ovarian stimulation and having normal basal FSH levels. In the third IVF attempt, all patients received transdermal testosterone treatment (20 µg/kg per day) during the 5 days preceding gonadotrophin treatment. RESULTS: Twenty patients (80%) showed an increase of over fivefold in the number of recruited follicles, produced 5.8 ± 0.4 (mean ± SEM) oocytes, received two or three embryos and achieved a clinical pregnancy rate of 30% per oocyte retrieval. There were 20% cancelled cycles. CONCLUSION: Pretreatment with transdermal testosterone may be a useful approach for women known to be low responders on the basis of a poor response to controlled ovarian stimulation but having normal basal FSH concentrations.

Keywords: androgens/IVF/low responders.
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