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Hum. Reprod. Advance Access published online on March 23, 2006
Human Reproduction, doi:10.1093/humrep/del080
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received November 26, 2005
Revised December 27, 2005
Accepted January 20, 2006

Case Report

Successful monozygotic twin delivery following in vitro maturation of oocytes retrieved from a woman with polycystic ovary syndrome: Case Report

Hiroyuki Kanaya 1 *, Yasutaka Murata 1, Hirotsugu Oku 1, Shu Hashimoto 1, Yoshiharu Morimoto 1, Tomoko Murata 2, Kengo Sugihara 2, Fumie Nagata 2, Yoshiharu Nakaoka 2, and Aisaku Fukuda 2

1 IVF NAMBA CLINIC, The Centre for Reproductive Medicine and Infertility
2 IVF OSAKA CLINIC, Osaka, Japan


  Abstract

The incidence of monozygotic twinning (MZT) appears to be increasing within the field of assisted reproductive technology (ART), although the factors contributing to the phenomenon are still far from being identified. On the contrary, in vitro maturation (IVM) of oocytes is becoming more accepted and more and more babies have been born worldwide using this procedure. Assessing its safety and impact on monozygotic twinning (MZT), and following up the health of these babies, is essential. We report here a first case of successful monozygotic (MZ) twin delivery following IVM. The patient was a 28-year-old Japanese female, referred to the IVF clinic for primary infertility. Several previous cycles of ovarian stimulation had resulted in ovarian hyperstimulation syndrome (OHSS). The patient received norethisterone-mestranol to initiate the menstruation, and oocyte retrieval was performed 36 h after hCG. A total of 22 immature oocytes were obtained. Following incubation for 24 h in IVM medium, 50% of the oocytes were matured to the metaphase II (MII) stage. Nine oocytes were fertilized after ICSI with the husband’s sperm. Three day 3 embryos were transferred into the uterus on the fourth day following oocyte retrieval. Three weeks after embryo transfer, a single gestational sac was visualized in the uterus. At 7 weeks of gestation, two fetal poles with cardiac activity were seen in the single gestational sac. Serial ultrasound examinations revealed a MZ, monochorionic diamniotic pregnancy. After intensive perinatal monitoring, two healthy male infants were delivered by Caesarean section at 35 weeks of gestation.

Keywords: IVF-ET/in vitro maturation/monozygotic twinning/PCOS/prolonged in vitro culture.
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S. Hashimoto, Y. Murata, M. Kikkawa, M. Sonoda, H. Oku, T. Murata, K. Sugihara, F. Nagata, Y. Nakaoka, A. Fukuda, et al.
Successful delivery after the transfer of twice-vitrified embryos derived from in vitro matured oocytes: A Case Report
Hum. Reprod., January 1, 2007; 22(1): 221 - 223.
[Abstract] [Full Text] [PDF]


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