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Hum. Reprod. Advance Access published online on April 3, 2006
Human Reproduction, doi:10.1093/humrep/del098
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received December 7, 2005
Revised February 21, 2006
Accepted March 9, 2006

Article

Misoprostol for cervical ripening in non-pregnant women: a randomized double-blind controlled trial of oral versus vaginal regimens

C. Choksuchat 1 *, S. Cheewadhanaraks 1, C. Getpook 1, V. Wootipoom 1, and K. Dhanavoravibul 1

1 Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand

* To whom correspondence should be addressed.
C. Choksuchat, E-mail: chchaina{at}yahoo.com


  Abstract

BACKGROUND: The objective was to compare the efficacy of oral versus vaginal misoprostol for cervical ripening in non-pregnant women. METHODS: Sixty non-pregnant women scheduled for diagnostic hysteroscopy were randomized by computerized randomization schedule to 400 µg of misoprostol orally (n = 30) or 200 µg vaginally (n = 30) administered 12 h prior to surgery. The diameter of the cervical canal measured with a Hegar dilator, adverse events and any complications were recorded and compared between the two groups. RESULTS: The mean pre- and post-medication cervical canal diameter and cervical diameter difference were 2.00 ± 1.93 versus 2.37 ± 1.83 mm (P = 0.453), 5.10 ± 1.75 versus 5.60 ± 1.69 mm (P = 0.265) and 3.10 ± 1.79 versus 3.23 ± 1.74 mm (P = 0.771) in the oral and vaginal group, respectively. Seven patients in the oral group and one patient in the vaginal group experienced diarrhoea within 24 h of administration of the misoprostol. CONCLUSION: Oral misoprostol 400 µg had similar efficacy in cervical ripening to 200 µg of vaginal misoprostol.

Keywords: cervical ripening/hysteroscopy/misoprostol/oral/vaginal.
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