Skip Navigation



Hum. Reprod. Advance Access published online on April 25, 2006
Human Reproduction, doi:10.1093/humrep/del118
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
21/8/2000    most recent
del118v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Mueller, A.
Right arrow Articles by Dittrich, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mueller, A.
Right arrow Articles by Dittrich, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received February 14, 2006
Revised March 17, 2006
Accepted March 24, 2006

Article

Uterine contractility in response to different prostaglandins: results from extracorporeally perfused non-pregnant swine uteri

Andreas Mueller 1 *, Theodoros Maltaris 1, Joern Siemer 1, Helge Binder 1, Inge Hoffmann 1, Matthias W. Beckmann 1, and Ralf Dittrich 1

1 Department of Obstetrics and Gynaecology, Erlangen University Hospital, Erlangen, Germany

* To whom correspondence should be addressed.
Andreas Mueller, E-mail: andreas.mueller{at}gyn.imed.uni-erlangen.de


  Abstract

BACKGROUND: Prostaglandins (PGs) are important stimulators of uterine contractility. Limited data are available at present on the effects of different PGs on uterine contractility, measured using intraluminal pressure changes in the complete uterus. The goal of this study was to assess dynamic changes in uterine contractility and peristalsis in response to PGs in comparison with the effects of oxytocin administration. METHODS: An extracorporeal perfusion model of swine uteri was used, which keeps the uterus in a functional condition, and is appropriate for the study of physiological questions. Oxytocin- and PG-induced uterine contractility and peristalsis were assessed using an intra-uterine double-chip microcatheter. RESULTS: A dose-dependent increase in intrauterine pressure (IUP) in the isthmus uteri (P < 0.001) and the corpus uteri (P < 0.001) was observed after the administration of PGF2{alpha} and oxytocin, which reached a plateau after further stimulation. A dose-dependent increase in IUP in the isthmus uteri (P < 0.001) and the corpus uteri (P < 0.001) was also observed after the administration of PGE1 and PGE2, with a plateau in IUP in the middle-concentration range and a decrease in the course of further stimulation. PGE2 caused significantly more contractions starting in the corpus uteri and moving to the isthmus uteri (P = 0.008). The direction of most contractions caused by PGE1, PGE2 and oxytocin differed from that of PGF2{alpha}. CONCLUSIONS: This study demonstrates that the PGs tested modulate contractility in non-pregnant swine uteri in a characteristic way, resulting in different contractility patterns.

Keywords: animal model/peristalsis/prostaglandin/sperm transport/uterine contractility.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
K. Hama, J. Aoki, A. Inoue, T. Endo, T. Amano, R. Motoki, M. Kanai, X. Ye, J. Chun, N. Matsuki, et al.
Embryo Spacing and Implantation Timing Are Differentially Regulated by LPA3-Mediated Lysophosphatidic Acid Signaling in Mice
Biol Reprod, December 1, 2007; 77(6): 954 - 959.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.