Skip Navigation



Hum. Reprod. Advance Access published online on May 5, 2006
Human Reproduction, doi:10.1093/humrep/del127
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
21/8/2022    most recent
del127v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ebner, T.
Right arrow Articles by Tews, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ebner, T.
Right arrow Articles by Tews, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received February 17, 2006
Revised March 21, 2006
Accepted March 28, 2006

Article

Basal level of anti-Müllerian hormone is associated with oocyte quality in stimulated cycles

T. Ebner 1 *, M. Sommergruber 1, M. Moser 1, O. Shebl 1, E. Schreier-Lechner 2, and G. Tews 1

1 IVF-Unit, Landes- Frauen- und Kinderklinik, Linz, Austria
2 Department of Laboratory Medicine, Landes- Frauen- und Kinderklinik, Linz, Austria

* To whom correspondence should be addressed.
T. Ebner, E-mail: thomas.ebner{at}gespag.at


  Abstract

BACKGROUND: Serum anti-Müllerian hormone (AMH) levels provide a powerful means for predicting ovarian response, which is reflected not only by the size of the primordial follicle pool but also by the quality of the oocytes. Considering a mutual interdependence between AMH-expressing somatic cells and gametes, this prospective morphological study was set up to evaluate whether extreme AMH levels represent diminished oocyte quality and developmental incompetence. METHODS: A total of 141 consecutive ICSI patients were subdivided into three groups using the 25th and 75th percentiles of the serum AMH levels (cycle day 3). In these three groups, morphology of all oocytes and fertilization rate, embryo quality and blastocyst formation were evaluated, and FSH, LH and estradiol (E2) levels were also measured. RESULTS: Cycle cancellation rate was correlated with AMH levels (P < 0.05). AMH groups 1 (<1.66 ng/ml) and 3 (>4.52 ng/ml) showed oocytes of lower quality [dark central granulation, aggregation of smooth endoplasmic reticulum (sER)] compared with the median group 2 (1.66-4.52 ng/ml). Basal serum FSH did not allow for adequate prognosis in terms of gamete appearance. Fertilization and further cleavage up to blastocyst stage was not affected by AMH levels. CONCLUSIONS: AMH seems to be superior to FSH in predicting both oocyte number and quality.

Keywords: AMH/central granulation/cycle cancellation/FSH/oocyte quality.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
D.A. Dumesic, M.S. Patankar, D.K. Barnett, T.G. Lesnick, B.A. Hutcherson, and D.H. Abbott
Early prenatal androgenization results in diminished ovarian reserve in adult female rhesus monkeys
Hum. Reprod., December 1, 2009; 24(12): 3188 - 3195.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
A. La Marca, G. Sighinolfi, D. Radi, C. Argento, E. Baraldi, A. C. Artenisio, G. Stabile, and A. Volpe
Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART)
Hum. Reprod. Update, September 30, 2009; (2009) dmp036v1.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. La Marca, F.J. Broekmans, A. Volpe, B.C. Fauser, N.S. Macklon, and on behalf of the ESHRE Special Interest Group for
Anti-Mullerian hormone (AMH): what do we still need to know?
Hum. Reprod., September 1, 2009; 24(9): 2264 - 2275.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Catteau-Jonard, S. P. Jamin, A. Leclerc, J. Gonzales, D. Dewailly, and N. di Clemente
Anti-Mullerian Hormone, Its Receptor, FSH Receptor, and Androgen Receptor Genes Are Overexpressed by Granulosa Cells from Stimulated Follicles in Women with Polycystic Ovary Syndrome
J. Clin. Endocrinol. Metab., November 1, 2008; 93(11): 4456 - 4461.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. Jayaprakasan, B.K. Campbell, J.F. Hopkisson, J.S. Clewes, I.R. Johnson, and N.J. Raine-Fenning
Effect of pituitary desensitization on the early growing follicular cohort estimated using anti-Mullerian hormone
Hum. Reprod., November 1, 2008; 23(11): 2577 - 2583.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. R. Sowers, A. D. Eyvazzadeh, D. McConnell, M. Yosef, M. L. Jannausch, D. Zhang, S. Harlow, and J. F. Randolph Jr.
Anti-Mullerian Hormone and Inhibin B in the Definition of Ovarian Aging and the Menopause Transition
J. Clin. Endocrinol. Metab., September 1, 2008; 93(9): 3478 - 3483.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C. Gnoth, A.N. Schuring, K. Friol, J. Tigges, P. Mallmann, and E. Godehardt
Relevance of anti-Mullerian hormone measurement in a routine IVF program
Hum. Reprod., June 1, 2008; 23(6): 1359 - 1365.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. M. Nelson, R. W. Yates, and R. Fleming
Serum anti-Mullerian hormone and FSH: prediction of live birth and extremes of response in stimulated cycles implications for individualization of therapy
Hum. Reprod., September 1, 2007; 22(9): 2414 - 2421.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Al-Qahtani and N. P. Groome
Anti-Mullerian Hormone: Cinderella Finds New Admirers.
J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 3760 - 3762.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.