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Hum. Reprod. Advance Access first published online on June 19, 2006
This version published online on July 10, 2006
Human Reproduction, doi:10.1093/humrep/del221
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received December 22, 2005
Revised April 21, 2006
Accepted May 15, 2006

Article

Androgen priming using aromatase inhibitor and hCG during early-follicular-phase GnRH antagonist down-regulation in modified antagonist protocols

K. Lossl 1 *, A.N. Andersen 2, A. Loft 2, N.L.C. Freiesleben 2, S. Bangsbøll 2, and C.Yding Andersen 3

1 The Fertility Clinic 4071, Denmark
2 The Fertility Clinic 4071, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
3 Laboratory of Reproductive Biology 5712, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

* To whom correspondence should be addressed.
K. Lossl, E-mail: kristine.loessl{at}rh.dk


  Abstract

BACKGROUND: Temporary exposure of follicles to increased levels of androgens may enhance their sensitivity to FSH. The aim of this study was to increase the intraovarian androgen level using aromatase inhibitors and hCG before controlled ovarian stimulation (COH) and to test this concept clinically. METHODS: In a prospective, non-randomized study, 45 patients were treated in modified antagonist protocols including early-follicular-phase down-regulation and androgen priming before COH. All patients received cetrorelix, 3 mg s.c., on cycle days 2 and 5. Group I (n = 15) received no other pretreatment. Group II (n = 15) received 1 daily tablet of aromatase inhibitor, letrozole 2.5 mg, from cycle days 2 to 8. Group III (n = 15) received letrozole as Group II and 1250 IU of hCG s.c. on cycle day 2. From cycle day 8, all patients were stimulated with highly purified menotrophin in a flexible antagonist protocol. RESULTS: Aromatase inhibitor increased the level of testosterone in follicular fluid (P < 0.002), but not in plasma. Androgen priming with aromatase inhibitor and hCG increased the number of good-quality embryos (P = 0.015) but did not increase the implantation rate. CONCLUSIONS: The use of aromatase inhibitor before COH significantly influences the local endocrine environment before and during stimulation. Androgen priming with both aromatase inhibitor and hCG may result in more good-quality embryos.

Keywords: androgen priming/aromatase inhibitor/follicular fluid/GnRH antagonist/ovarian stimulation.

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