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Hum. Reprod. Advance Access published online on June 21, 2006
Human Reproduction, doi:10.1093/humrep/del234
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received March 16, 2006
Revised May 16, 2006
Accepted May 18, 2006

Article

A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination

Anita Sik Yau Kan 1 *, Natalie Caves 2, Sylvia Yuen Wai Wong 3, Ernest Hung Yu Ng 1, and Pak Chung Ho 1

1 Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China
2 Department of Anaesthesiology, The University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China
3 Operation Theatre Service, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China

* To whom correspondence should be addressed.
Anita Sik Yau Kan, E-mail: kansy{at}ha.org.hk


  Abstract

BACKGROUND: This prospective study assessed the role of a 50:50 mixture of nitrous oxide (N2O) and oxygen for pain relief during the termination of first trimester pregnancies by suction evacuation under conscious sedation. METHODS: Ninety women undergoing suction evacuation up to 12 weeks of gestation were randomized by a computer-generated randomization list and allocated using sealed envelopes to receive the N2O/O2 mixture or air during the operation. Pain scores during and after suction evacuation, post-operative side effects and satisfaction level were compared. RESULTS: No statistically significant differences in pain scores, post-operative side effects and satisfaction levels were found between the two groups. CONCLUSION: N2O/O2 did not reduce the pain level during suction evacuation for the first trimester pregnancy termination under conscious sedation.

Keywords: N2O/oxygen/pain relief/suction evacuation.
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