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Hum. Reprod. Advance Access published online on September 22, 2006
Human Reproduction, doi:10.1093/humrep/del254
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received April 3, 2006
Revised May 22, 2006
Accepted May 27, 2006

Article

Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF

David Barad 1 * and Norbert Gleicher 2

1 Center for Human Reproduction, New York, NY; The Foundation for Reproductive Medicine, Chicago, IL; Department of Epidemiology and Social Medicine and Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine, Bronx, NY
2 Center for Human Reproduction, New York, NY; The Foundation for Reproductive Medicine, Chicago, IL; Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, USA

* To whom correspondence should be addressed.
David Barad, E-mail: dbarad{at}optonline.net


  Abstract

BACKGROUND: The aim of this study was to investigate the effect of treatment with dehydroepiandrosterone (DHEA) on fertility outcomes among women with diminished ovarian reserve. MATERIALS AND METHODS: This is a case-control study in an academically affiliated private infertility centre. Twenty-five women with significantly diminished ovarian reserve had one IVF cycle before and after DHEA treatment, with otherwise identical hormonal stimulation. Women received 75 mg of DHEA daily (25 mg three times daily) for an average of 17.6 ± 2.13 weeks. We performed a comparison of IVF outcome parameters, before and after DHEA treatment, including peak estradiol (E2) levels, oocyte and embryo numbers, oocyte and embryo quality and embryo transfer statistics. RESULTS: Paired analysis of IVF cycle outcomes in 25 patients, who underwent cycles both before and after DHEA supplementation, demonstrated significant increases in fertilized oocytes (P < 0.001), normal day 3 embryos (P = 0.001), embryos transferred (P = 0.005) and average embryo scores per oocyte (P < 0.001) after DHEA treatment. CONCLUSION: This study confirms the previously reported beneficial effects of DHEA supplementation on ovarian function in women with diminished ovarian reserve.

Keywords: dehydroepiandrosterone/embryo score/IVF/ovarian reserve/polycystic ovary syndrome.
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