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Hum. Reprod. Advance Access published online on September 7, 2006

Human Reproduction, doi:10.1093/humrep/del352
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received June 15, 2006
Revised July 28, 2006
Accepted August 4, 2006

Article

Endometriosis involving the ileocaecal junction with regional lymph node involvement in the baboon--striking pathological finding identical between the human and the baboon: A Case Report

B.F. Barrier 1 *, E.J. Dick Jr 2, S.D. Butler 2, and G.B. Hubbard 2

1 Department of Obstetrics, Gynecology and Women’s Health, Division of Reproductive and Perinatal Research, University of Missouri, Columbia, MO
2 Veterinary Resources, Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, USA

* To whom correspondence should be addressed.
B.F. Barrier, E-mail: barrierb{at}health.missouri.edu


   Abstract

The baboon is an established model for endometriosis research. This report describes the occurrence of spontaneous endometriosis involving the ileocaecal junction and associated regional lymph nodes in the baboon. All endometriotic foci lacked the nuclear atypia, abnormal mitotic activity and altered nuclear-to-cytoplasmic ratio typical of malignancy. These findings are identical to reports in the human in which ileocaecal and colonic endometriosis is associated with endometriosis in pericolonic and mesenteric lymph nodes. The similarity between baboon and human colonic endometriosis in both location and pathology is striking and lends further evidence supporting the validity of the baboon as a model for human endometriosis.

Keywords: baboon/bowel/colon/endometriosis/lymph node.
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[Abstract] [Full Text] [PDF]



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