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Hum. Reprod. Advance Access published online on September 25, 2006
Human Reproduction, doi:10.1093/humrep/del375
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received June 20, 2006
Revised August 8, 2006
Accepted August 14, 2006

Article

Parental desire and acceptability of spermatogonial stem cell cryopreservation in boys with cancer

H. van den Berg 1 *, S. Repping 2, and F. van der Veen 2

1 Department of Paediatric Oncology, Emma Children Hospital, Academic Medical Centre, University of Amsterdam,, Amsterdam, The Netherlands
2 Department of Obstetrics and Gynaecology, Centre for Reproductive Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

* To whom correspondence should be addressed.
H. van den Berg, E-mail: h.vandenberg{at}amc.uva.nl


  Abstract

BACKGROUND: In the near future, a substantial proportion of adults will be childhood cancer survivors. The cryo-preservation and transplantation of spermatogonial stem cells (SSCs) is currently successful in animals; application in humans seems likely in the near future. Cryopreserving SSCs might become an important issue in childhood cancer. Because this might require testicular biopsies or hemicastration, parental desire/acceptability for SSC collection was enquired for. METHODS: Three hundred eighteen parents of boys surviving at least 2 years after the diagnosis of cancer were asked about collecting SSCs by biopsy or hemicastration and collecting sperm by masturbation or electrostimulation. Opinions were assessed as if at the time of diagnosis and at the present time. RESULTS: Sixty-three per cent of parents responded. At diagnosis, SSC collection by means of biopsy was approved by 61%, hemicastration by 33% and collecting sperm by 70% (P < 0.013). The acceptability of performing hemicastration was significantly lower than all other forms of SSC/sperm collection. No differences were observed between parents’ present opinion and opinion at diagnosis. No differences related to treatment intensity, presumed negative fertility effects and puber-tal state were found. CONCLUSIONS: Infertility is a major topic for parents. For prepubertal boys, the collection of SSCs might be a great relief in respect of the fertility issue. Collecting SSCs by biopsy is desired and accepted by the majority of parents; hemicastration is accepted by one-third of parents. The translation of SSC cryopreservation and transplantation from animal models to humans is eagerly awaited.

Keywords: spermatogonial stem cells/childhood cancer/hemicastration/testicular biopsy/infertility.
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