Skip Navigation



Hum. Reprod. Advance Access published online on October 17, 2006
Human Reproduction, doi:10.1093/humrep/del381
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
22/2/578    most recent
del381v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Palomba, S.
Right arrow Articles by Zullo, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Palomba, S.
Right arrow Articles by Zullo, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received May 7, 2006
Revised July 20, 2006
Accepted August 31, 2006

Article

Comparison of two fertility-sparing approaches for bilateral borderline ovarian tumours: a randomized controlled study

S. Palomba 1 *, E. Zupi 2, T. Russo 1, A. Falbo 1, S. Del Negro 1, F. Manguso 3, D. Marconi 2, A. Tolino 4, and F. Zullo 1

1 Department of Obstetrics and Gynecology, University ‘Magna Graecia’ of Catanzaro, Catanzaro, Italy
2 Department of Obstetrics and Gynecology, University ‘Tor Vergata’ of Rome, Rome, Italy
3 Department of Clinical and Experimental Medicine, University ‘Federico II’ of Naples, Naples, Italy
4 Department of Obstetrics and Gynecology, University ‘Federico II’ of Naples, Naples, Italy

* To whom correspondence should be addressed.
S. Palomba, E-mail: stefanopalomba{at}tin.it


  Abstract

BACKGROUND: During the childbearing years, the standard fertility-sparing treatment for bilateral borderline ovarian tumours (BOTs) is the unilateral oophorectomy plus controlateral cystectomy. The aim of the present study was to compare the effects of two laparoscopic fertility-sparing surgical procedures for the treatment of bilateral BOTs on recurrence and fertility in young women who desire to conceive as soon as possible. METHODS: Thirty-two women affected by bilateral early-stage BOTs who desired to conceive were randomized to receive bilateral cystectomy (experimental group, n = 15) or oophorectomy plus controlateral cystectomy (control group, n = 17). At the first recurrence after childbearing completion, each patient was treated with non-conservative standard treatment. Recurrences and reproductive events were recorded. RESULTS: After a follow-up period of 81 months (19 inter-quartile; 60-96 range), the cumulative pregnancy rate (CPR) (14/15 versus 9/17; P = 0.003) and the cumulative probability of first pregnancy (P = 0.011) were significantly higher in the experimental than in control group. No significant (P = 0.358) difference between groups was detected in cumulative probability of first recurrence. CONCLUSIONS: The laparoscopic bilateral cystectomy followed by non-conservative treatment performed at the first recurrence after the childbearing completion is an effective surgical strategy for patients with bilateral early-stage BOTs who desire to conceive as soon as possible.

Keywords: borderline ovarian tumour/cystectomy/fertility/recurrence/surgery.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.