Skip Navigation



Hum. Reprod. Advance Access published online on November 9, 2006
Human Reproduction, doi:10.1093/humrep/del400
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
22/2/414    most recent
del400v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gesink Law, D.C.
Right arrow Articles by Longnecker, M.P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gesink Law, D.C.
Right arrow Articles by Longnecker, M.P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received June 1, 2006
Revised August 24, 2006
Accepted September 14, 2006

Article

Obesity and time to pregnancy

D.C. Gesink Law 1 *, R.F. Maclehose 2, and M.P. Longnecker 3

1 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA; Department of Microbiology, Montana State University, Bozeman, MT, USA
2 Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA
3 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA

* To whom correspondence should be addressed.
D.C. Gesink Law, E-mail: dionne.gesinklaw{at}montana.edu


  Abstract

BACKGROUND: Obesity may reduce fecundity. We examined the obesity-fecundity association in relation to menstrual cycle regularity, parity, smoking habits and age to gain insight into mechanisms and susceptible subgroups. METHODS: Data were provided by 7327 pregnant women enrolled in the Collaborative Perinatal Project at 12 study centres in the United States from 1959 to 1965. Prepregnancy body mass index (BMI) was analysed continuously and categorically [underweight (<18.5 kg/m2), optimal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2) and obese (≥30.0 kg/m2)]. Adjusted fecundability odds ratios (FORs) were estimated using Cox proportional hazards modelling for discrete time data. RESULTS: Fecundity was reduced for overweight [OR = 0.92, 95% confidence interval (95% CI): 0.84, 1.01] and obese (OR = 0.82, 95% CI: 0.72, 0.95) women compared with optimal weight women and was more evident for obese primiparous women (OR = 0.66, 95% CI: 0.49, 0.89). Fecundity remained reduced for overweight and obese women with normal menstrual cycles. Neither smoking habits nor age modified the association. CONCLUSIONS: Obesity was associated with reduced fecundity for all subgroups of women and persisted for women with regular cycles. Our results suggest that weight loss could increase fecundity for overweight and obese women, regardless of menstrual cycle regularity, parity, smoking habits and age.

Keywords: fecundity/fertility/obesity/reproduction.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
L. A. Wise, K. J. Rothman, E. M. Mikkelsen, H. T. Sorensen, A. Riis, and E. E. Hatch
An internet-based prospective study of body size and time-to-pregnancy
Hum. Reprod., October 14, 2009; (2009) dep360v1.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
L. Bunting and J. Boivin
Knowledge about infertility risk factors, fertility myths and illusory benefits of healthy habits in young people
Hum. Reprod., August 1, 2008; 23(8): 1858 - 1864.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Santoro, S. L. Crawford, W. L. Lasley, J. L. Luborsky, K. A. Matthews, D. McConnell, J. F. Randolph Jr., E. B. Gold, G. A. Greendale, S. G. Korenman, et al.
Factors Related to Declining Luteal Function in Women during the Menopausal Transition
J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1711 - 1721.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. E. Minge, B. D. Bennett, R. J. Norman, and R. L. Robker
Peroxisome Proliferator-Activated Receptor-{gamma} Agonist Rosiglitazone Reverses the Adverse Effects of Diet-Induced Obesity on Oocyte Quality
Endocrinology, May 1, 2008; 149(5): 2646 - 2656.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. H.N. Nguyen, A. J. Wilcox, R. Skjaerven, and D. D. Baird
Men's body mass index and infertility
Hum. Reprod., September 1, 2007; 22(9): 2488 - 2493.
[Abstract] [Full Text] [PDF]

Home page
 JWatch Women's HealthHome page
Higher BMI, Lower Fecundity
Journal Watch Women's Health, March 29, 2007; 2007(329): 4 - 4.
[Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.