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Hum. Reprod. Advance Access published online on October 25, 2006
Human Reproduction, doi:10.1093/humrep/del413
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received January 25, 2006
Revised August 31, 2006
Accepted September 12, 2006

A Case Report

A successful IVF-pregnancy in a patient who underwent conservative surgery followed by a regimen of cisplatin, vinblastine and peplomycin to treat an advanced ovarian mixed germ cell tumour: A Case Report

Y. Kitajima 1, T. Endo 1 *, T. Hayashi 1, S. Ishioka 1, T. Baba 1, H. Honnma 1, and T. Saito 1

1 Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Sapporo, Japan

* To whom correspondence should be addressed.
T. Endo, E-mail: endot{at}sapmed.ac.jp


  Abstract

Mixed germ cell tumours of the ovary, one type of malignant ovarian germ cell tumours (MOGCTs), are rare gynaecologic cancers usually affecting young women. We report the case of a patient with an advanced ovarian mixed germ cell tumour who underwent fertility-saving surgery followed by a chemotherapy regimen of cisplatin, vinblastine and peplomycin. The patient was disease-free 8 years after initial presentation. She conceived and gestated dichorionic twins after IVF-embryo transfer. To the best of our knowledge, the patient is the first to be treated successfully with the combination chemotherapy regimen and then conceive safely using assisted reproductive technology (ART).

Keywords: assisted reproduction/pregnancy/chemotherapy/cancer/germ cell tumour.
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