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Hum. Reprod. Advance Access published online on October 31, 2006
Human Reproduction, doi:10.1093/humrep/del425
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org
Received June 28, 2006
Revised September 27, 2006
Accepted September 28, 2006

Article

Increased telomerase activity and human telomerase reverse transcriptase mRNA expression in the endometrium of patients with endometriosis

C.M. Kim 1, Y.J. Oh 1, S.H. Cho 1, D.J. Chung 2, J.Y. Hwang 1, K.H. Park 2, D.J. Cho 2, Y.M. Choi 3, and B.S. Lee 1 *

1 Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Yongdong Severance Hospital, 146-92 Dogok-dong, Kangnam-ku, Seoul, Korea
2 Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Korea
3 Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea

* To whom correspondence should be addressed.
B.S. Lee, E-mail: dr222{at}yumc.yonsei.ac.kr


  Abstract

BACKGROUND: Endometriosis is considered a frequent, benign disease with the ability to undergo neoplastic processes. The aim of this study was to evaluate the limitless replication potential of the endometrium in patients with endometriosis by examining human telomerase reverse transcriptase (hTERT) mRNA expression and telomerase activity. METHODS: Endometrium samples from 30 endometriosis patients and 30 patients without endometriosis were obtained via endometrial biopsy. The expression of hTERT mRNA was determined by real-time RT-PCR assay, and telomerase activity was measured by telomerase repeat amplification protocol (TRAP) assay. RESULTS: The mean normalized hTERT (N hTERT) mRNA level was significantly higher in the endometriosis than in the control group (P = 0.013). The mean hTERT mRNA levels during the proliferative phase and during the secretory phase were higher in the endometriosis group than in the control group, although the difference was only significant for the secretory phase (P = 0.036). We found a prominent difference in endometrial telomerase activity between moderate-to-severe endometriosis and the control group (P = 0.048). The levels of hTERT mRNA and telomerase activity increased as the disease became more severe (P = 0.038, P = 0.016). CONCLUSIONS: This study showed the overex-pression of hTERT mRNA and telomerase activity in the endometrium of endometriosis patients. These finding suggest that replication potential of endometrial cells may have an important role in the pathogenesis of endometriosis.

Keywords: endometriosis/human telomerase reverse transcriptase (hTERT) mRNA/pathogenesis/telomerase.
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