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Hum. Reprod. Advance Access published online on November 17, 2006
Human Reproduction, doi:10.1093/humrep/del430
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received August 5, 2006
Revised September 28, 2006
Accepted October 5, 2006

Article

Effect of different sites for cryopreserved ovarian tissue implantation in rabbit

Xiao-hui Deng 1 *, An-ran Xu 1, Lan Chao 1, Hong-ling Yu 1, Jun-hui Zhen 2, Shu Hashimoto 3, and Yoshiharu Morimoto 3

1 Center for Reproductive Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China
2 Department of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China
3 IVF Namba Clinic, Center for Reproductive Medicine and Infertility, Osaka, Japan

* To whom correspondence should be addressed.
Xiao-hui Deng, E-mail: dxh{at}sdu.edu.cn


  Abstract

BACKGROUND: Autotransplantation of frozen-thawed ovarian tissue has proven to be an effective method to restore endocrine function and fertility. But it remains to be studied which site and which method is most effective and practical. We therefore implanted small pieces of cryopreserved ovarian tissues into different sites in rabbits to find the optimal position. METHODS: Fifteen New Zealand white female rabbits were randomly divided into three groups. In group 1, fresh ovarian tissues were implanted into the mesometrium and ovarian bursa. In group 2, cryopreserved ovarian tissues were implanted into the mesometrium and ovarian bursa. In group 3, cryopreserved ovarian tissues were implanted into the preserved ovary. RESULTS: There were no significant differences among the three groups as to the proportions of normal and morphologically changed follicles in implanted ovarian tissues. The implanted ovarian tissues in the three groups did not show any evident changes in histology and ultrastructure, and all resumed follicle development and revealed maturescent follicles. CONCLUSIONS: Cryopreservation and implantation of small pieces of ovarian tissues are feasible. Generally, the mesometrium, ovarian bursa and ovary are all available sites for implantation and have similar rates of acceptance, despite some differences in the details of implantation.

Keywords: cryopreservation/autologous/implantation/ovary.
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