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Hum. Reprod. Advance Access published online on January 5, 2007
Human Reproduction, doi:10.1093/humrep/del489
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Adipocyte resistin mRNA levels are down-regulated by laparoscopic ovarian electrocautery in both obese and lean women with polycystic ovary syndrome

Kok-Min Seow1,2,3, Chi-Chang Juan3,4,5, Low-Tone Ho3,4,5,6, Yung-Pei Hsu5, Yu-Hung Lin1,7, Lee-Wen Huang1,7 and Jiann-Loung Hwang1,7,8,9

1 Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan 2 School of Medicine, Fu-Jen Catholic University, Taipei Hsien, Taiwan 3 Institute of Clinical Medicine 4 Institute of Physiology, National Yang-Ming University, Taipei, Taiwan 5 Department of Medical Research & Education 6 Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan 7 School of Medicine, Fu-Jen Catholic University, Taipei Hsien, Taiwan 8 Department of Obstetrics and Gynecology, Taipei Medical University, Taipei, Taiwan

9 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Shin-Kong Wu Ho-Su Memorial Hospital, No. 95, Wen Chang Road, Shih Lin District, Taipei 111, Taiwan. Tel.: +886 2 28332211 ext. 3879; Fax: +886 2 28389416; E-mail: m002249{at}ms.skh.org.tw

BACKGROUND: The aim of this study was to investigate serum and adipocyte mRNA expression of resistin in lean and obese women with polycystic ovary syndrome (PCOS) before and 3 months after laparoscopic ovarian electrocauterization (LOE).

METHODS: Adipose tissue obtained from 12 women with PCOS (six obese and six lean, body mass index>27 kg m–1 as threshold point) before and after LOE was analysed. Gene expression of resistin was measured by semi-quantitative RT–PCR. Ten lean, age-matched healthy women served as controls.

RESULTS: Both lean and obese women with PCOS had significantly higher fasting and 2 h insulin and homeostasis model insulin resistance index (HOMAIR) values and lower fasting glucose-to-insulin ratios (G0/I0) than did the controls. The serum levels of glucose and insulin and HOMAIR were significantly decreased, and the G0/I0 ratio was significantly increased 3 months after LOE. No difference was found in serum resistin levels between controls and either obese or lean women with PCOS before LOE, nor between PCOS patients before and after LOE. However, resistin mRNA expression levels in both lean and obese women with PCOS before LOE were significantly higher than that in controls and were decreased significantly after LOE back to control levels.

CONCLUSION: Local resistin activity may be actively involved in the pathogenesis of PCOS. LOE reduces insulin resistance and down-regulates resistin mRNA expression in lean and obese women with PCOS.

Key words: adipocyte/insulin resistance/laparoscopic ovarian electrocauterization/polycystic ovary syndrome/resistin


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