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Hum. Reprod. Advance Access published online on March 6, 2007
Human Reproduction, doi:10.1093/humrep/dem009
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Testosterone patch improves ovarian follicular response to gonadotrophins in a patient with Kallmann's syndrome: A Case Report

Christopher S. Sipe and Bradley J. Van Voorhis1

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA

1 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, 200 Hawkins Drive, University of Iowa Hospitals and Clinics, Iowa City, IA 52242-1080, USA. Tel: +1 319 384 6848; Fax: +1 319 353 6659; E-mail: brad-van-voorhis{at}uiowa.edu

Achieving ovulation in women with Kallmann's syndrome requires both exogenous FSH and LH to successfully stimulate follicular maturation and ovarian steroidogenesis. We present a case of a woman with Kallmann's syndrome, who had poor ovarian response to stimulation by exogenous gonadotrophins. When she was given testosterone by patch before initiation of gonadotrophins, her stimulation dramatically improved. Once we ceased to pretreat her cycle with testosterone, she again had a poor stimulation. This suggests that testosterone administration may be a useful adjunct in improving ovarian response to gonadotrophins in Kallmann's syndrome patients.

Key words: follicular development/gonadotropins/Kallman's syndrome/ovarian response/testosterone

Submitted on September 15, 2006; resubmitted on December 18, 2006; accepted on December 27, 2006.


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