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Hum. Reprod. Advance Access published online on September 12, 2007
Human Reproduction, doi:10.1093/humrep/dem276
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Endometrial receptivity after oocyte donation in recipients with a history of chemotherapy and/or radiotherapy

Vernaeve Valérie1, Bodri Daniel, Colodrón Marta, Vidal Ricard, Durbán Mercé and Coll Oriol

Clinica Eugin, Calle Entenza 293-295, 08029 Barcelona, Spain

1Correspondence address. Tel: +34-93-322-11-22; Fax: +34-6-66-82-17-99; E-mail: vernaeve{at}telefonica.net

INTRODUCTION: Information is scarce regarding the outcome of oocyte donation (OD) in patients with a history of cancer treatment. Therefore, we conducted a matched controlled analysis on the outcome of OD in these recipients.

METHODS: Between January 2000 and November 2005, 33 patients with a history of chemotherapy and/or radiotherapy had an OD cycle. Matching was performed to the chronologically closest patient without a history of cancer therapy by number of days of hormonal stimulation before embryo replacement, number of replaced embryos, day of embryo transfer and origin of sperm.

RESULTS: The primary diseases of the patients were Hodgkin’s lymphoma (n = 12), non-Hodgkin’s lymphoma (n = 3), leukaemia (n = 7), ovarian cancer (n = 6), Ewing’s sarcoma (n = 2), breast cancer (n = 1), sympathoblastoma (n = 1) and histiocytosis X (n = 1). Twenty-three patients had undergone chemotherapy and radiotherapy, nine patients chemotherapy only and one radiotherapy only. The mean age of the recipients was 33.1 years [95% confidence interval (CI) 30.9–35.3] and 39.6 (95% CI 37.1–42.1) in the study and control groups, respectively. The average number of received oocytes and transferred embryos, was similar in both groups. Nineteen (57.6%) versus 13 (39.4%) pregnancies resulting in an ongoing pregnancy (i.e. viable at 12 weeks) in 15 (45.4%) versus 9 cycles (27.3%) (NS) were obtained in study and control groups, respectively. Implantation rate in study and control groups was 35.8 versus 17.9%, respectively (P = 0.02).

CONCLUSIONS: The results suggest that patients with a history of cancer treatment have a pregnancy rate after OD similar to that in the general population of oocyte recipients.

Key words: chemotherapy/oocyte donation/pregnancy/radiotherapy/ICSI

Submitted on October 22, 2006; resubmitted on May 27, 2007; accepted on June 6, 2007.


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