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Hum. Reprod. Advance Access published online on September 12, 2007
Human Reproduction, doi:10.1093/humrep/dem285
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The ISMAAR proposal on terminology for ovarian stimulation for IVF

G. Nargund6,1, B.C.J.M. Fauser2, N.S. Macklon2, W. Ombelet3, K. Nygren4, R. Frydman for the Rotterdam ISMAAR Consensus Group on Terminology for Ovarian Stimulation for IVF5

1 Department of Reproductive Medicine, St George’s Hospital and Medical School, Blackshaw Road, London SW17 0QT, UK 2 Department of Reproductive Medicine and Gynaecology, University Medical Center, Utrecht, The Netherlands 3 Department of Obstetrics and Gynaecology, ZOL Campus St Jan, Genk, Belgium 4 IVF Clinic, Sophiahemmet Hospital, Stockholm, Sweden 5 Department of Obstetrics and Gynaecology, and Reproductive Medicine, Hôpital Béclère - Sce Gynéco-Obstétrique, 157 rue de la Porte de Trivaux, 92141 CLAMART, France

6 Correspondence address. Tel: +44 208 947 9600; Fax: +44 208 944 5800; E-mail: geetanargund{at}gmail.com

IVF is performed with oocytes collected in natural and stimulated cycles. Different approaches to ovarian stimulation have been employed worldwide. Following the introduction of GnRH antagonists and strategies to reduce multiple births such as single embryo transfer, there is a genuine scientific interest in the revival of natural cycle and mild approaches to ovarian stimulation in IVF. Recent evidence suggests that application of natural and mild IVF is patient-centred, aimed at reducing the cost of treatment, patient discomfort and multiple pregnancies. However, there seems to be no consistency in the terminology used for definitions and protocols for ovarian stimulation in IVF cycles. Following the recent International Society for Mild Approaches in Assisted Reproduction (ISMAAR) meeting and communication with interested international experts, this article has recommended revised definitions and terminology for natural cycle IVF and different protocols used in ovarian stimulation for IVF. It is proposed that these terms are adopted internationally in order to achieve a consistency in clinical practice, research publications and communication with patients.

Key words: natural cycle IVF/mild IVF/minimal stimulation IVF/conventional IVF/proposal on terminology

Submitted on June 6, 2007; resubmitted on July 19, 2007; accepted on August 20, 2007.


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