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Hum. Reprod. Advance Access published online on December 2, 2007
Human Reproduction, doi:10.1093/humrep/dem307
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Cryopreservation of ovarian tissue and in vitro matured oocytes in a female with mosaic Turner syndrome: Case Report

J.Y.J. Huang1, T. Tulandi1, H. Holzer1, N.M. Lau1, S. MacDonald2, S.L. Tan1 and R.C. Chian1,3

1 Department of Obstetrics and Gynecology, McGill University Health Center, McGill University, Montreal, Quebec, Canada H3A 1A1 2 Department of Pediatrics, McGill University Health Center, McGill University, Montreal, Quebec, Canada H3A 1A1

3 Correspondence address. Women’s Pavilion F3.46, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1. Fax: +1-514-843-1662; E-mail: ri-cheng.chian{at}muhc.mcgill.ca

We report a novel approach of fertility preservation in a young woman with mosaic Turner syndrome. A 16-year-old female with 20% 45XO and 80% 46XX karyotype underwent laparoscopic ovarian wedge resection. Before performing ovarian tissue cryopreservation, all visible follicles on the ovarian surface were aspirated. We recovered 11 immature germinal vesicle stage oocytes, which were subjected to in vitro maturation (IVM). Eight oocytes that matured (73% maturation rate) were cryopreserved by vitrification. The combination of ovarian tissue cryobanking and immature oocyte collection from the tissue followed by IVM and vitrification of matured oocytes represent a promising approach of fertility preservation for young women with mosaic Turner syndrome.

Key words: Turner syndrome/fertility preservation/in vitro maturation/vitrification/oocyte

Submitted on April 10, 2007; resubmitted on July 29, 2007; accepted on August 29, 2007.


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