Skip Navigation



Hum. Reprod. Advance Access published online on January 24, 2008
Human Reproduction, doi:10.1093/humrep/dem409
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
23/4/889    most recent
dem409v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Lambers, M.J.
Right arrow Articles by Lambalk, C.B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lambers, M.J.
Right arrow Articles by Lambalk, C.B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

A family history of twinning in relation to multiple implantation

M.J. Lambers1, S. Roek, L. Luttikhof, R. Schats, R. Homburg, P.G.A. Hompes and C.B. Lambalk

Department of Obstetrics, Gynecology and Reproductive Medicine, VU University Medical Center (VUmc), PO Box 7057, 1007 MB Amsterdam, The Netherlands

1 Correspondence address. Tel: +41 20 4440070; E-mail: mj.lambers{at}vumc.nl

BACKGROUND: A familial basis for dizygotic twinning is known for multiple ovulation. However, for multiple implantation this remains unclear. In IVF/intracytoplasmic sperm injection (ICSI) ‘multiple ovulation’ is artificially induced. If multiple implantation is not hereditary, the incidences of twins in families of patients with single and multiple implantation after IVF/ICSI with double embryo transfer (DET) should be comparable.

METHODS: A questionnaire study was conducted among patients with intra uterine pregnancy at 6 weeks of gestation, after IVF/ICSI treatment with DET 3 days after oocyte retrieval.

RESULTS: There were 940 patients who gave their informed consent. For women with single implantation (Group A), the incidence of one and of multiple twins among the family was 27.2 and 15.5%, respectively. For women with multiple implantation (Group B), this incidence was 29.5 and 17.8%, respectively, P = 0.424. The incidence of one and of multiple twins among first degree relatives was 10.6 and 1.1% in Group A; for Group B this was 8.7 and 1.9%, P = 0.469. Multivariate regression analysis also did not reveal ‘twins in family’ or ‘twins in first degree’ as an associated variable for multiple implantation at 6 weeks.

CONCLUSIONS: Incidences of twins in families of patients with single implantation and patients with multiple implantation after IVF/ICSI are comparable. Our data do not support the concept that multiple implantation is hereditary.

Key words: IVF/pregnancy/multiple implantation/twins

Submitted on September 12, 2007; resubmitted on November 24, 2007; accepted on December 4, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
S. Vitthala, T.A. Gelbaya, D.R. Brison, C.T. Fitzgerald, and L.G. Nardo
The risk of monozygotic twins after assisted reproductive technology: a systematic review and meta-analysis
Hum. Reprod. Update, January 1, 2009; 15(1): 45 - 55.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.