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Hum. Reprod. Advance Access published online on January 7, 2008
Human Reproduction, doi:10.1093/humrep/dem412
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The impact of LH-containing gonadotropins on diploidy rates in preimplantation embryos: long protocol stimulation

Andrea Weghofer1,2,7, Santiago Munné3, Werner Brannath4, Serena Chen5, Giles Tomkin3, Natalie Cekleniak5, Margaret Garrisi5, David Barad2, Jacques Cohen3 and Norbert Gleicher2,6

1 Department of Obstetrics and Gynecology, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria 2 The Center for Human Reproduction, New York, NY, USA 3 Reprogenetics, LLC, West Orange, NJ, USA 4 Core Unit for Medical Statistics and Informatics, Section for Medical Statistics, Medical University Vienna, Vienna, Austria 5 The Institute for Reproductive Medicine and Science, Livingston, NJ, USA 6 Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA

7Correspondence address. E-mail: andrea.weghofer{at}meduniwien.ac.at

BACKGROUND: The aim of this study was to evaluate the effect of ovarian stimulation with LH-containing gonadotropins (human menopausal gonadotropin, hMG), on ploidy of human cleavage-stage-embryos.

METHODS: A total of 104 women, at ages 27–43 years, undergoing one cycle of controlled ovarian hyperstimulation for IVF in combination with preimplantation genetic diagnosis, were eligible for enrollment in this retrospective, controlled cohort study. Ovarian stimulation included down-regulation with long agonist and stimulation with either recombinant FSH or hMG. Since the ploidy of embryos changes with female age, patients were matched for age and dosage of the respective gonadotropin.

RESULTS: Despite similar numbers of chromosomally normal embryos in both groups, women undergoing hMG stimulation demonstrated significantly higher percentages of diploid embryos than did the FSH-stimulated patients (69.8 versus 45.3%; P < 0.01).

CONCLUSIONS: Long protocol LH-containing ovarian stimulation improves embryonic ploidy in comparison to pure FSH stimulation. This observation may explain higher IVF pregnancy rates, reported for hMG stimulation in some studies.

Key words: aneuploidy/preimplantation genetic diagnosis/human menopausal gonadotropin (hMG)/LH/rFSH

Submitted on September 14, 2007; resubmitted on October 18, 2007; accepted on November 2, 2007.


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A. Weghofer, S. Munne, W. Brannath, D.H. Barad, J. Cohen, and N. Gleicher
Reply: Possible impact of LH-containing gonadotrophins on diploidy rates in preimplantation embryos
Hum. Reprod., May 1, 2009; 24(5): 1239 - 1240.
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