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Hum. Reprod. Advance Access published online on March 6, 2008
Human Reproduction, doi:10.1093/humrep/den061
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Opinion

Change, change, change: hormonal actions depend on changes in blood levels

Shahar Kol1,4 and Roy Homburg2,3

1 IVF Unit, Rambam Medical Center, Haifa, Israel 2 Reproductive Medicine Division, VU University Medical Center, Amsterdam 1007 MB, The Netherlands 3 Barzilai Medical Center, Ashkelon, Israel

4Correspondence address. E-mail: skol{at}rambam.health.gov.il

The main hypothesis outlined in this communication is that changes in hormonal levels are of utmost importance in the female reproductive system physiology. Hormone measurements must be assessed in the context of time and change. We hypothesize that changes in hormone concentrations carry significant biological messages, much more than a given level at a given time point and if proved, this theory could give rise to better approaches to treatment, and risk assessment.

Key words: hormones/female reproductive physiology/change/dynamics

Submitted on December 12, 2007; resubmitted on January 14, 2008; accepted on February 7, 2008.


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