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Hum. Reprod. Advance Access published online on April 26, 2008
Human Reproduction, doi:10.1093/humrep/den135
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Age-specific success rate for women undertaking their first assisted reproduction technology treatment using their own oocytes in Australia, 2002–2005

Y.A. Wang1,4, D. Healy2, D. Black3 and E.A. Sullivan1

1 Perinatal and Reproductive Epidemiology Research Unit, School of Women's and Children's Health, The University of New South Wales, McNevin Dickson Building, Randwick Hospitals Campus, Randwick, NSW 2031, Australia 2 Department of Obstetrics and Gynaecology, Faculty of Medicine, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia 3 School of Public Health and Community Medicine, The University of New South Wales, Sydney, NSW 2052, Australia

4 Correspondence address. Tel: +61-2-9382-1014; Fax: +61-2-9382-1025; E-mail: alex.wang{at}unsw.edu.au

BACKGROUND: Woman's age is an independent factor determining the success of assisted reproductive technology treatment. This study presents the age-specific success rate of first autologous fresh treatment in Australia during 2002–2005.

METHODS: This is a retrospective population-based study of 36 412 initiated first autologous fresh cycles conducted in Australian clinics during 2002–2005. Pregnancy and live delivery rates per initiated cycle were determined for each age.

RESULTS: The overall live delivery rate per initiated cycle was 20.4% with the highest success rate in women aged between 22 and 36 years. Male factor only infertility had a higher live delivery rate (22.0%) than female factor only infertility (19.2%). Advancing woman's age was associated with a decline in success rate. For women ≥30 years, each additional 1 year in age was associated with an 11% (99% CI: 10–12%) reduction in the chance of achieving pregnancy and a 13% (99% CI: 12–14%) reduction in the chance of a live delivery. If women aged 35 years or older would have had their first autologous fresh treatment 1 year earlier, 15% extra live deliveries would be expected.

CONCLUSIONS: This study suggested that women aged 35 years or older should be encouraged to seek early fertility assessment and treatment where clinically indicated.

Key words: woman's age/autologous/pregnancy/live delivery/assisted reproductive technology

Submitted on November 2, 2007; resubmitted on March 19, 2008; accepted on April 1, 2008.


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