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Hum. Reprod. Advance Access published online on October 23, 2008
Human Reproduction, doi:10.1093/humrep/den372
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Hyperandrogenism after transfer of topical testosterone gel: case report and review of published and unpublished studies

Willem de Ronde1

Department of Endocrinology, VU University Medical Center, de Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands

1 Correspondence address. E-mail: p.deronde{at}vumc.nl

Topically applied testosterone gels are a widely used mode of testosterone replacement therapy. A concern associated with the use of testosterone gel is unintentional transfer to children or women by skin contact with the application site. We present a case of female hyperandrogenism most likely caused by transfer of testosterone gel used by her partner. Additionally, we searched the computerized database PUBMED and the FDA medical reviews for case reports and clinical trials concerning transfer risk. Several case reports and the results of clinical trials indicate that transfer of testosterone from gel-treated males to women and children is possible and clinically relevant. Thus, the potential of testosterone transfer in gel users should be recognized as a possible side effect of this form of testosterone replacement therapy.

Key words: testosterone gel/topical transfer

Submitted on June 9, 2008; resubmitted on August 8, 2008; accepted on August 12, 2008.


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