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Hum. Reprod. Advance Access published online on January 24, 2009
Human Reproduction, doi:10.1093/humrep/den482
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Long-term follow-up of patients with polycystic ovary syndrome: reproductive outcome and ovarian reserve

M. Hudecova1, J. Holte, M. Olovsson and I. Sundström Poromaa

Department of Women's and Children's Health, Uppsala University 751 85 Uppsala, Sweden

1 Correspondence address. Tel: +46 18 611 57 87; E-mail: miriam.hudecova{at}kbh.uu.se

BACKGROUND: The purpose of the present study was to examine long-term reproductive outcome and ovarian reserve in an unselected population of women with polycystic ovary syndrome (PCOS).

METHODS: A total of 91 patients with confirmed PCOS and 87 healthy controls were included in the study. Patients had been diagnosed between 1987 and 1995 and at the time of the follow-up, subjects were 35 years of age or older.

RESULTS: Among women who had attempted a pregnancy, 86.7% of PCOS patients and 91.6% of controls had given birth to at least one child. Among PCOS patients who had given birth, 73.6% had done so following a spontaneous conception. Mean ovarian volume and the number of antral follicles in PCOS patients were significantly greater than in control women (P < 0.001, respectively). PCOS patients also had higher serum concentrations of anti-Müllerian hormone and lower follicle-stimulating hormone levels.

CONCLUSIONS: Most women with PCOS had given birth, and the rate of spontaneous pregnancies was relatively high. Together with the ultrasound findings and the hormonal analyses, this finding could imply that PCOS patients have a good fecundity, and an ovarian reserve possibly superior to women with normal ovaries.

Key words: polycystic ovary syndrome/long-term follow-up/ovarian reserve/fecundity/anti-Müllerian hormone

Submitted on October 15, 2008; resubmitted on November 29, 2008; accepted on December 3, 2008.


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