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Hum. Reprod. Advance Access published online on February 5, 2009
Human Reproduction, doi:10.1093/humrep/den498
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Ultrasound-guided artificial insemination: a randomized controlled trial

Olga Ramón1, Roberto Matorras1,2,3,4, Beatriz Corcóstegui1, Arantza Meabe1, Jorge Burgos1, Antonia Expósito1 and Lorena Crisol1

1 Human Reproduction Unit, Obstetrics and Gynaecology Department, Hospital de Cruces-Baracaldo, Vizcaya, Spain 2 Basque Country University, Lejona Vizcaya, Basque, Spain 3 IVI Bilbao, Paseo Landabarri, Lejona, Vizcaya, Spain

4 Correspondence address. María Diaz de Haro 7, 6 iz, 48013 Bilbao, Spain; E-mail: roberto.matorras{at}osakidetza.net

BACKGROUND: The aim was to ascertain whether using ultrasound guidance during intrauterine insemination (IUI) could increase pregnancy rates (PRs).

METHODS: The population under study consisted of 73 consecutive couples subjected to IUI in our Human Reproduction Unit, between June and December 2006, with a total of 231 IUI cycles performed. The patients were randomized using a computer-generated random numeric table into two groups: ultrasound-guided IUI group (n = 33) and clinical IUI group (n = 40).

RESULTS: The PR was 16.0% per cycle in ultrasound-guided IUI and 16.8% in the control group, no statistically significant differences being observed between the groups. The 95% confidence interval for the difference in PRs of 0.8% was –8.8 to 10. There were no differences in PR per woman, nor in first-cycle PR. The cumulative PR was also similar in both populations. Although the initial intention was to perform a study involving a larger number of cases, after a first interim analysis, the study was interrupted due to its futility. There were no differences in PR according to the different cervico-uterine angles.

CONCLUSIONS: Ultrasound-guided IUI does not produce better results than blind insemination, because the PR per cycle is similar. ClinicalTrials.gov ID NCT00809952 [ClinicalTrials.gov] .

Key words: intrauterine insemination/pregnancy rate/ultrasound

Submitted on June 27, 2008; resubmitted on November 20, 2008; accepted on December 29, 2008.


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