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Hum. Reprod. Advance Access published online on February 26, 2009
Human Reproduction, doi:10.1093/humrep/dep044
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

MDM2 309 polymorphism is associated with missed abortion

Yan Fang1, Beihua Kong1,5, Qifeng Yang2, Daoxin Ma3 and Xun Qu4

1 Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Ji’nan 250012, Shandong, People's Republic of China 2 Department of General Surgery, Qilu Hospital, Shandong University, Ji'nan, Shandong, People's Republic of China 3 Department of Hematology, Qilu Hospital, Shandong University, Ji'nan, Shandong, People's Republic of China 4 Department of Basic Medicine, Qilu Hospital, Shandong University, Ji'nan, Shandong, People's Republic of China

5 Correspondence address. E-mail: kongbeihua{at}yahoo.com.cn

BACKGROUND: In this study, we assessed whether the single nucleotide polymorphism in the murine double minute 2 (MDM2) promoter (SNP309) was associated with the occurrence of missed abortion.

METHODS: Genotyping of MDM2 SNP309 polymorphism was conducted by polymerase chain reaction-restriction fragment length polymorphism with blood and villous samples from 95 women diagnosed as having 1st trimester missed abortion.

RESULTS: The MDM2 SNP309 G/G genotype was associated with a higher risk of missed abortion compared with the T/T + T/G genotype in blood (P = 0.010; odds ratio (OR): 2.164; 95% confidence interval (CI): 1.207–3.878) and villous samples (P = 0.043; OR: 2.767; 95% CI: 1.092–7.011).

CONCLUSIONS: The MDM2 SNP309 G/G genotype may be a genetic risk factor for missed abortion.

Key words: missed abortion/MDM2/polymorphism/pregnancy

Submitted on September 2, 2008; resubmitted on January 30, 2009; accepted on February 2, 2009.


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