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Hum. Reprod. Advance Access published online on April 4, 2009
Human Reproduction, doi:10.1093/humrep/dep062
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Creation of a registry for human embryonic stem cells carrying an inherited defect: joint collaboration between ESHRE and hESCreg

K.D. Sermon1,10, C. Simon2,3, P. Braude4,5, S. Viville6,7, J. Borstlap8 and A. Veiga9

1 Department of Embryology and Genetics, Vrije Universiteit Brussel, Brussel, Belgium 2 Valencia Stem Cell Bank (VSCB), Centro de Investigación Principe Felipe (CIPF), Valencia, Spain 3 Instituto Valenciano de Infertilidad Foundation, Valencia University, Valencia, Spain 4 Department of Women’s Health, King’s College, London, UK 5 Centre for Preimplantation Genetic Diagnosis, Guy’s Hospital, London, UK 6 IGBMC, Inserm U596 and CNRS UMR7104, Illkirch F-67400, France 7 Université Louis Pasteur, Faculté de Médecine, Centre Hospitalier Universitaire, Strasbourg F-67000, France 8 Berlin-Brandenburg Center for Regenerative Therapies at the Charité, Universitätsmedizin Berlin, Berlin, Germany 9 Centre de Medicina Regenerativa de Barcelona, Servei de Medicina de la Reproducció, USP Institut Universitari Dexeus, Barcelona, Spain

10 Correspondence address. E-mail: Karen.Sermon{at}uzbrussel.be

Human embryonic stem cells (hESCs), derived from human blastocysts, hold a great promise for regenerative medicine, drug development and basic research in developmental biology. Moreover, hESC lines that carry a clinically relevant inherited defect, monogenic or chromosomal, present an important tool for research into the pathophysiology of these diseases. The hESC registry (hESCreg) was started up in 2007 in order to register all stem cell lines derived in Europe (www.hescreg.eu). Because of the special nature of the hESC lines that carry an inherited disease, they are of particular interest to researchers outside the assisted reproductive technologies or stem cell fields, for instance, those involved in regenerative medicine and in medical and human genetics. To reach these researchers, and to better disseminate the information on the cell lines, a concerted action of the hESCreg together with ESHRE’s Special Interest Groups in Reproductive Genetics and Stem Cells was initiated. This mini-review is a first report that will be followed by yearly reports of new lines, not unlike the reports from the Preimplantation Genetic Diagnosis Consortium or the European IVF Monitoring.

Key words: human embryonic stem cells/monogenic disease/genetic abnormality/hESC registry

Submitted on December 2, 2008; resubmitted on December 28, 2008; accepted on January 6, 2009.


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