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Hum. Reprod. Advance Access published online on June 20, 2009
Human Reproduction, doi:10.1093/humrep/dep222
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Is there a uniform basal endometrial gene expression profile during the implantation window in women who became pregnant in a subsequent ICSI cycle?

A. Allegra1,3, A. Marino1, F. Coffaro1, A. Lama1, G. Rizza1, P. Scaglione1, F. Sammartano1, A. Santoro2 and A. Volpes1

1 Andros Day Surgery, Reproductive Medicine Unit, Palermo, Italy 2 Azienda Ospedaliera ‘V. Cervello’, Clinical Research and Biotechnologies, Palermo, Italy

3 Correspondence address. E-mail: allegra{at}centroandros.it

BACKGROUND: To understand which genes are really involved in the implantation process, we planned to study the gene basal expression profile during the window of implantation (WOI) of patients who became pregnant in a subsequent ICSI cycle.

METHODS: Women attending their first ICSI cycle at ANDROS Day Surgery for severe male factor infertility were included in the study. An endometrial biopsy was performed during the WOI, in one of the last two cycles before the ICSI cycle. Forty-seven selected gene profiles were analyzed using Low Density Array technology. Only biopsies from women who subsequently became pregnant were evaluated, to exclude any bias regarding embryo viability and embryo transfer difficulties.

RESULTS: Fifteen patients were included in the analysis as they became pregnant after ICSI procedure. Four of 47 selected genes were excluded from the analysis. Of the 43 genes analyzed, only 6 genes (VEGFA, PLA2G2A, ALPL, LIF, NNMT and STC1) showed a statistically uniform expression among patients who subsequently became pregnant. For all the other genes analyzed there were considerable differences in their expression levels amongst women who subsequently became pregnant.

CONCLUSIONS: Our data suggest that very few genes, which change their expression level during the WOI, show a quantitative homogeneous expression in endometrially-receptive patients. In conclusion, in this study only six genes showed a homogeneous expression, and are probably involved in embryo implantation mechanisms.

Key words: endometrium/implantation window/gene expression profile/ICSI/pregnancy

Submitted on December 24, 2008; resubmitted on May 19, 2009; accepted on May 27, 2009.


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