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Cover design  The problems of conventional methods of karyotyping blastomeres become acute under limited timescales during preimplantation genetic diagnosis. The front cover of Human Reproduction shows the karyotype of a blastomere of a normal embryo obtained from a woman carrying 46,XX,t(9;11)(p24;q12) translocation. The upper picture shows the results of FISH analyis with painting probes for chromosomes 9 (green) and 11 (orange) with a centromeric probe for chromosome 9 (blue) and telomeric probe for 11q (yellow). These results were obtained using a new rapid method in which human blastomeres are fused with bovine in-vitro matured oocytes and cytoplasmic factors used to force the human nucleii into metaphase. For further details, see pp. 470-475.



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